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AACR honors Alan D’Andrea

March 1, 2021 | shgcmyqk | No Comments

first_imgThe American Association for Cancer Research (AACR) presented Alan D. D’Andrea, the Alvan T. and Viola D. Fuller American Cancer Society Professor of Radiation Oncology at Harvard Medical School and the Dana-Farber Cancer Institute, with the 52nd Annual AACR G.H.A. Clowes Memorial Award for his work in understanding cancer survival and progression, which has included milestones such as cloning a key protein involved in red blood cell production and discovering a family of proteins that help maintain DNA stability.The award, presented to D’Andrea at the AACR’s annual meeting in Chicago, recognizes a scientific odyssey that began with research into a rare pediatric cancer susceptibility syndrome — Fanconi anemia — and led to new insights into how cells repair their DNA and thereby ward off cancer.In his acceptance speech, D’Andrea remarked: “I am greatly honored to receive the 2012 G.H.A. Clowes Memorial Award from the AACR. Work from my laboratory has shown that the study of rare pediatric cancer susceptibility syndromes, such as Fanconi anemia, can lead to broad insights into the cause and treatment of cancer in the general population. My laboratory members and I are especially grateful to the children and families with Fanconi anemia who have been our close partners in this research during the last two decades.”During his postdoctoral studies, D’Andrea cloned the erythropoietin (EPO) receptor, a key protein involved in red blood cell production (erythropoiesis) and survival. The receptor’s role in erythropoiesis offers a potential avenue for cancer therapeutics, as a blood supply is necessary for the growth and spread of cancer. D’Andrea continues to investigate the receptor in hematological malignancies, examining the ways that inherent (somatic) mutations and/or epigenetic modifications of the receptor affect its downstream, intracellular signaling pathways including JAK/STAT (Janus kinase/signal transducer and activator of transcription) and MAPK (mitogen-activated protein kinase).The AACR & Eli Lilly and Co. established the G.H.A. Clowes Memorial Award in 1961 to honor G.H.A. Clowes, a founding member of the AACR. This honor recognizes an individual with outstanding recent accomplishments in basic cancer research.“Dr. D’Andrea has been a vital contributor to cancer research,” said Margaret Foti, chief executive officer of the AACR. “His work has greatly enhanced our knowledge of the field of DNA instability and repair mechanisms. Furthermore, his studies have provided us with a better understanding of the biological relationships of rare hereditary diseases, such as Fanconi anemia, and cancer.”last_img read more

Morgan: I’ve never sung anthem

September 20, 2020 | rfunaawx | No Comments

first_imgEngland captain Eoin Morgan has defended his decision not to sing the national anthem before matches at the World Cup. The 28-year-old left-hander was born and raised in Dublin but, after making his international debut for Ireland, has represented England since 2009. “It’s pretty simple. I’ve never sung the national anthem whether I’ve played for Ireland or England,” he said. Press Association “It doesn’t make me any less proud to be an English cricketer. I’m extremely proud to be in the position I am in and privileged to be captain of a World Cup side.” When asked to expand on why he did not sing ‘God Save the Queen’, Morgan added: “It’s a long story. It’s a personal thing.” Outspoken broadcaster Piers Morgan suggested on Twitter this week that the one-day captain should sing the anthem. Eoin Morgan has made 181 appearances for England in all formats – he played 23 times for Ireland – and was handed the captaincy for the World Cup after Alastair Cook was stood down following his lean tour of Sri Lanka before Christmas. Morgan’s first tour in full-time charge has not been smooth, however, after it began with the England and Wales Cricket Board (ECB) revealing he was the victim of a £35,000 blackmail plot before the Tri-Series match in Hobart. Morgan then suffered a horror run of outs – during which he made three successive ducks against Australia – and saw his team heavily beaten in their opening two World Cup matches. He was even incorrectly identified as ‘Eoin Rogers’ by the mayor of Wellington at a Maori welcoming ceremony. A 119-run over Scotland in Christchurch on Monday got England’s campaign off the mark although the criticism of his long-held decision not to sing the national anthem is another unwelcome distraction. Morgan, who has been steadfast throughout, has also been the subject of some ridicule Down Under with former Australia captain Steve Waugh suggesting this week he might be having second thoughts about his move to England. “A couple of their players might have regretted going to England, like Boyd Rankin and Eoin Morgan – they might be wishing they’d stayed with Ireland,” Waugh said. Ireland have won both of their games to start the World Cup. The form of the Irish has pushed the International Cricket Council’s decision to reduce the 2019 World Cup, to be held in England, down to 10 teams into the spotlight. The consensus of opinion has been that scrapping for places, which would most likely prevent associate nations from reaching the World Cup, was not in the best interests of the game on a global level. The fact the closest matches at this World Cup have so far involved the associate teams has also further strengthened the argument against the ICC’s cull that Morgan agrees with. “I think it would be a terrible shame,” he said. “Part of playing in a World Cup – the agenda of the ICC should be to spread the good word of the game we play. “The more teams we can, within reason, have playing then the more exposure they get in their home nation and the more exposure they get against top sides.” Morgan also called for the ECB to consider organising a home Tri-Series including Ireland to help cure their chronic lack of matches between World Cups. Ireland managed just nine completed ODIs against full-member nations in the four years since the last World Cup and at present have a deal to play England every two years. “They want much more cricket and it wouldn’t be a bad thing if we played a Tri-Series between whoever is touring (and Ireland),” Morgan said. That would help Ireland’s quest to play more games, and lift their ranking, after the ICC last month handed them a chance to directly qualify for the next World Cup should they rise into the top eight. “If it’s the Ashes then it’d be Australia and then Ireland in between,” Morgan added. “The Tri-Series we played recently, albeit against Australia and India, was brilliant. If there is a window for that absolutely.” Morgan also backed moves for an ‘English Premier League’ franchise-based Twenty20 tournament following revelations via a leaked document that the ECB were discussing the possibility, amongst a raft of potentially wide-reaching changes to the structure of the game. “Striking a balance between having a similar international calendar as we have at the moment and three or four weeks of this EPL would be brilliant,” he said. “You look at templates like IPL – obviously they have their international players – but the Big Bash don’t. They facilitate that with having two overseas players. “If they’re big enough names I think it can certainly work. It would obviously have to be less teams.” last_img read more

first_img Facebook Twitter Google+ Published on September 23, 2014 at 1:42 pm Contact Jacob: [email protected] | @Jacob_Klinger_ Syracuse nearly lost to Villanova and did lose to Maryland — the two times it’s faced teams led by dual-threat quarterbacks this season.No. 8 Notre Dame and its quarterback, Everett Golson, are likely to be the Orange’s toughest such test of the season to date. SU (2-1) faces the Fighting Irish (3-0) at 8 p.m. Saturday at MetLife Stadium in East Rutherford, New Jersey. And in his Tuesday teleconference, Orange head coach Scott Shafer talked about the need to contain Golson, who led UND to an undefeated regular season and the 2013 national title game, which it lost to Alabama.“I think you have to take a look at the prepared run game stuff and then you also have to do a good job — he creates,” Shafer said. “He creates in passing downs with his feet, he extends plays and throws the ball down the field. And he can also scamper for good yardage.”Golson missed last season after being suspended from school for “poor academic judgment,” but has thrown for seven touchdowns and no interceptions this year. He has also has four rushing touchdowns.In SU’s 27-26 double-overtime win against Villanova, Wildcats quarterback John Robertson rushed for 133 yards. Maryland quarterback C.J. Brown only ran for 46, but his constant threat to the Orange defense helped the Terrapins to a 34-20 win in the Carrier Dome.AdvertisementThis is placeholder textSaid Shafer: “Have to have a good game plan and we have to have really good vision on our job at hand in the run game as well as getting our eyes back and always knowing where Golson is throughout the course of the play.” Commentslast_img read more

first_imgThe defending champions went down 1-21 to 0-21 to Drom’n’Inch in a thrilling quarter-final in Holycross.Drom join Holycross-Ballycahill, Loughmore-Castleiney and Moycarkey-Borris in the last four of the competition.Mid PRO Trevor Hassset says there was a very exciting conclusion to yesterday’s match.last_img