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AACR honors Alan D’Andrea

March 1, 2021 | shgcmyqk | No Comments

first_imgThe American Association for Cancer Research (AACR) presented Alan D. D’Andrea, the Alvan T. and Viola D. Fuller American Cancer Society Professor of Radiation Oncology at Harvard Medical School and the Dana-Farber Cancer Institute, with the 52nd Annual AACR G.H.A. Clowes Memorial Award for his work in understanding cancer survival and progression, which has included milestones such as cloning a key protein involved in red blood cell production and discovering a family of proteins that help maintain DNA stability.The award, presented to D’Andrea at the AACR’s annual meeting in Chicago, recognizes a scientific odyssey that began with research into a rare pediatric cancer susceptibility syndrome — Fanconi anemia — and led to new insights into how cells repair their DNA and thereby ward off cancer.In his acceptance speech, D’Andrea remarked: “I am greatly honored to receive the 2012 G.H.A. Clowes Memorial Award from the AACR. Work from my laboratory has shown that the study of rare pediatric cancer susceptibility syndromes, such as Fanconi anemia, can lead to broad insights into the cause and treatment of cancer in the general population. My laboratory members and I are especially grateful to the children and families with Fanconi anemia who have been our close partners in this research during the last two decades.”During his postdoctoral studies, D’Andrea cloned the erythropoietin (EPO) receptor, a key protein involved in red blood cell production (erythropoiesis) and survival. The receptor’s role in erythropoiesis offers a potential avenue for cancer therapeutics, as a blood supply is necessary for the growth and spread of cancer. D’Andrea continues to investigate the receptor in hematological malignancies, examining the ways that inherent (somatic) mutations and/or epigenetic modifications of the receptor affect its downstream, intracellular signaling pathways including JAK/STAT (Janus kinase/signal transducer and activator of transcription) and MAPK (mitogen-activated protein kinase).The AACR & Eli Lilly and Co. established the G.H.A. Clowes Memorial Award in 1961 to honor G.H.A. Clowes, a founding member of the AACR. This honor recognizes an individual with outstanding recent accomplishments in basic cancer research.“Dr. D’Andrea has been a vital contributor to cancer research,” said Margaret Foti, chief executive officer of the AACR. “His work has greatly enhanced our knowledge of the field of DNA instability and repair mechanisms. Furthermore, his studies have provided us with a better understanding of the biological relationships of rare hereditary diseases, such as Fanconi anemia, and cancer.”last_img read more

State must stop wasting tax money

October 20, 2020 | zelepmlo | No Comments

first_imgCategories: Letters to the Editor, Opinion As a New York state taxpayer, along with most of you readers, I’m appalled at the lack of outrage regarding the current state budget that was just recently pushed through. Some examples of extreme waste are $3 million that was allotted to the Dick’s Sporting Goods Golf Tournament — yes, $3 million. Also, $300,000 was given to Cornell University for “concord grape research,” as well as $100,000 to the town of East Hampton for “tourism initiatives.” Trust me, this is a town that doesn’t need this kind of help. There are many other examples of money given for these “pet projects,” which in my opinion, could have been better spent elsewhere.We have roads loaded with potholes and infrastructure that’s falling apart around us, yet those worthy causes didn’t get the money they need. Just to get out in time for the Easter and Passover holidays, lawmakers chose to fund these other unworthy causes.  What about organizations and institutions established to help the poor and those in need? Food pantries and homeless shelters are in constant need of funds and supplies to help the many who go hungry and have nowhere to sleep in New York state every day. Apparently, they’re less important than a golf tournament.Let’s send out a message to our elected representatives on Election Day, or messages to their respective offices even sooner. This isn’t how I want our money spent.Come on, lawmakers, get your act together. Do your jobs and earn our respect. Fund the causes that truly need it — and not spend billions in pork-barrel spending. And you wonder why people are disgusted.Margaret HesdorferSchoharieMore from The Daily Gazette:EDITORIAL: Beware of voter intimidationFoss: Should main downtown branch of the Schenectady County Public Library reopen?EDITORIAL: Thruway tax unfair to working motoristsEDITORIAL: Urgent: Today is the last day to complete the censusEDITORIAL: Find a way to get family members into nursing homeslast_img read more

first_img The Canaries were thrashed 3-0 at Tottenham on Boxing Day but remain outside the relegation zone on goal difference. Victory over Villa would move Neil’s team 12 points above their opponents, who are rooted to the bottom of the league after winning just one game all season. “There are games in and about you that you’ve got to win, so I would probably call it a must-win, even though I don’t think anything’s going to be determined by this particular game,” Neil said. “However, three points against them certainly makes things a lot better. “It’s a snowball effect between now and the end of the season. Every game becomes bigger if you don’t win games.” Norwich, like Villa, had just 48 hours between fixtures, but Neil was confident his players would recover in time. “It will be interesting to see how we respond but other teams will have to do it as well, it’s not as if it’s just us,” Neil said. “It’s not as if they’re called upon to do it all the time, it’s a one-off and we need to get ourselves ready because it’s an important game for us.” Midfielders Wes Hoolahan and Gary O’Neil were left out of the side at White Hart Lane but both could return for the clash at Carrow Road. Andre Wisdom and Matt Jarvis, however, are unlikely to be fit. “Wes was one where if I had played him against Tottenham, he wouldn’t have made the next one. The next game suits him,” Neil added. “Gary O’Neil was a different situation, he couldn’t make the (Spurs) game as he wasn’t quite ready. We had to give him an extra day’s rest.” Press Associationcenter_img Norwich boss Alex Neil admits Monday’s crunch basement battle against Aston Villa could set the tone for the second half of the season.last_img read more

first_imgThe Polestar in Letterkenny captured in all its gloryThis year, 2012, Donegal County Council celebrates 21 years of Public Art commissioning in the County and are marking this with the launch of an exhibition that looks back proudly over the last 21 years of Public Art in Donegal.The Per Cent for Art Scheme, which has funded much of the work has been a tremendous scheme that has seen great and diverse projects delivered in all electoral areas around the county.This exhibition reminds us of what can and has been achieved with artistic ambition and shows why Donegal has such a strong reputation for not just public art but for culture in general. If you come to the Regional Cultural Centre to see the exhibition, you will see the variety of work that has been commissioned over the 21 years – photography, drama, poetry, craft, music, architecture, animation, pyrotechnics and sculpture. Everyone will have their favourite piece or project for different reasons.The new public art website is also being launched. When the old website was created just seven years ago, it won a prestigious Irish Design Award, but Donegal County Council know that its critical to keep current, especially with social media. The website has a fresh contemporary feel but the colours of soft green are evocative of Donegal.So, whats the road ahead for Public Art in Donegal? The new draft Public Art Plan – Making Shapes Two (2013 – 2017) is also being launched and this sets out the intention of the Public Art Office for the next 5 years and includes amongst other things the proposal to develop ArtScape at Ards Forest Park, which if developed will be a ‘must see’, iconic visitor attraction in Ards Forest Park. Not only will it build on our reputation in Donegal as a Cultural County but would also lever tremendous economic benefit to Donegal from Cultural Tourism.Donegal County Council are aware of the challenging times we live in but Donegal County Council still believes in a society that values creativity, imagination and expression, believes that the arts generate growth and tourism, believes that the arts enhance our reputation and that the arts enrich our lives. Th exhibition remains open until 8th February 2013.For further details contact Ms. Terre Duffy, Public Art Manager on [email protected] CELEBRATES 21 YEARS OF PUBLIC ART WITH EXHIBITION FOR ALL was last modified: December 5th, 2012 by StephenShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window) Tags:Donegal County ConcilPublic artlast_img read more